Thursday, January 31, 2013

Healing gardens: Horticulture therapy takes root in South Florida

Allspice and heirloom roses scent the garden where Robert Bornstein starts his work day at his home, tending plants meant not for show but for healing.

"We have 35 years of scientific documentation to tell us we were meant to be with nature,? says Bornstein, potting an Everglades tomato that his seniors with limited mobility can grow indoors. ?I need at least ten minutes in the garden or I?m no good.?

Bornstein?s work, called horticultural therapy, uses gardens and gardening activities to improve memory,, physical coordination, rehabilitation and social skills. According to Elizabeth Diehl, editor-in-chief of the Journal of Therapeutic Horticulture, a growing body of research shows horticulture therapy?s benefits among older populations.

?Having access to natural spaces reduces violent behavior in Alzheimer?s patients,? Diehl says.

As hospitals and treatment centers become aware of the benefits, they are adding horticultural activities to their recreational therapy programs. Bornstein, who began his career working with patients who had been declared criminally insane, now has a busy practice serving 40 senior residence facilities across South Florida and charges roughly $90 an hour for his services.

Ten minutes slip to thirty.

?I?m late!? he realizes, and jumping into his Prius, guns it to Deerfield Beach.

"You see, ladies? He?s always running," Geraldine Markiewicz, a retired first-grade teacher, tells fellow Horizon Club residents as the therapist races into the assisted living facility bearing bags of materials for a flower arranging hour. Fifteen residents range around the common area, some in wheelchairs. Bornstein passes around thimble-sized plastic containers that look like champagne glasses, followed by sprigs of eucalyptus, cattails and dried flowers. Each person selects an element, decides its arrangement, and attaches it to a thumbnail of floral foam with all the hand-eye coordination he or she can muster.

Neuropathy, rheumatoid arthritis and the shaking hands of Parkinson?s disease can make such fine movements difficult. Yet as the arrangements take shape, no bigger than a salt shaker, they look as fine as if a caterer had created them for a wedding table.

Activities Assistant Gwenda Rodriguez stands by as a resident who can barely move wills her hands to place a purple flower in the cup. The woman?s face beams. She has made the most elegant arrangement of all.

* * *

Elena Naranjo used to be an assistant director at a mental health center, dealing with continual crisis management. Then she got a license in permaculture, the design of holistic living spaces based on sustainable agriculture. ?I think there?s a very healing application working with nature. It?s where I wanted to end up,? Naranjo says.

Now she, a small staff, and the homeless and formerly homeless families of Verde Gardens, a 145-unit affordable housing community of Miami-Dade Homeless Trust and Carrfour Supportive Housing, are reaping their first full harvest on the Farm at Verde Gardens.

Modeled on the Homeless Garden Project in Santa Cruz, Calif., the 22-acre farm on former Homestead Air Reserve Base land offers skills and business opportunities to community members like Xavier Wright, as well as fresh food

?I?m an outdoor person. My grandparents grew cotton and peaches,? says 25-year-old Wright who arrived at the Chapman Partnership homeless shelter a single father with full custody of his autistic son. ?I love this,? he says, setting pigeon pea seedlings in the soil.

Source: http://www.miamiherald.com/2013/01/27/3200386/healing-gardens-horticulture-therapy.html

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CollegeBasketballTalk

College hoops news and rumors
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An irreverent, offbeat look at sports
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Source: http://www.rotoworld.com/content/playerpages/player_main.aspx?sport=NHL&id=2175

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Plume for Twitter (for Android)

By Max Eddy

Just because Twitter is working to curtail non-canonical clients doesn't mean that developers have stopped trying to deliver its 140-character utterances in better and better ways. Plume for Twitter brings a highly customizable Twitter client to Android devices (free, $4.99 to remove ads) with a powerful muting feature to help you manage the chaos of Twitter.

Starting up Plume for the first time, users are greeted by a colorful screen and Plume's cute, friendly duck/penguin masot. Once inside the app, Tweets are displayed in a series of scrolling columns, showing @ replies, the latest updates, direct messages, and so on. Users can scroll up and down to move chronologically through the feeds, and left and right between feeds. Swiping left to right from off the screen will open a hidden tray of other features, such as search and trending topics.

The Sound of Silence
By far, Plume's strongest and most useful feature is "muting" certain users, words, and services from appearing in your feed. One of the drawbacks of Twitter, and it is surely like this by design, is that ?the only way to remove a user from your feed is to un-follow them?a public and noticeable act. Twitter's Lists feature helps, but it lacks fine-grain controls. If you mute a user in Plume, you'll still appear as their follower and you can unmute them at any time. For a sticky social situation, or a power user who has accounts he or she is obliged to follow, "muting" is a powerful tool.

Plume also has the ability to mute Tweets that contain certain words or phrases, as defined by the user. For everyday folks, this is a great way to avoid the weekly cavalcade of #FF tweets, Apple product announcements, or particularly tiresome memes from invading your Twittersphere. For people with PTSD or emotional triggers, being able to hide certain terms from view could make participating in Twitter a far less stressful experience.

Users can manage all their mutes from the settings menu, including muted updates from other apps that publish on Twitter.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/N_Kfc4j1Cvs/0,2817,2414773,00.asp

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Travel Breaking News: Best new mountain resorts

Just 6 years old, the Sutton Place Hotel at Revelstoke Mountain Resort is where all the cool kids stay.

(CNN) -- About three-thousand feet above sea level, fleece-clad guests sit fireside sipping glasses of Burgundy from the chalet owner's private vineyard. But this isn't St. Moritz. Down the hall is a stone-and-oak onsen for aprs-ski muscle soaking. Welcome to the Kimamaya Boutique Hotel on the Japanese island of Hokkaido, an increasingly chic ski destination.

Kimamaya is one example of how the latest ski resorts are trending toward high design and popping up in some unexpected places. Such new resorts in Norway, Japan and Austria's Tyrol region have begun to attract an off-the-beaten-trail set. They have enough varied amenities to appeal to all, especially non-skiers who were previously dragged into the cold by their ski-enthusiast friends and family.

Travelers can expect mountain retreats with designer furniture, original art on the walls and top chefs brought in from cities to give the cheese-and-potato ski cuisine a makeover. And, naturally, some ski-specific perks: better ski-in, ski-out access, ultra-groomed and longer trails and state-of-the-art lifts.

Whether you ski or not, there's never been a better time to change your altitude with a stay at one of these chic mountain resorts.

Travel + Leisure: America's Most-Visited Ski Resorts

Myrkdalen Hotel Voss, Norway

Skiing was invented in Norway, so it's fitting that this resort (opened in November 2012) is adorned with vintage black-and-white photos that recall the sport's glamorous early days. The property's 122 rooms vary from designer suites with faux-fur pillows and earthy tones to family-friendly ones with bunk beds and pull-out sofas.

The location in Voss Mountain Village provides quick access to 15 slopes, a network of cross-country trails and a ski school. UNESCO-inscribed Sognefjord and Nryfjord fjords are nearby for the days you need a break from the slopes. Rooms from $160.

Kimamaya Boutique Hotel, Hokkaido, Japan

This luminous barnlike hotel designed by Andrew Bell in the ski region of Niseko-Hirafu on the northernmost island of Hokkaido opened in 2011 and is also a new member of Design Hotels.

The lobby fireplace crackles, jazz sets the mood and elm floors and black granite make a dramatic design statement. The nine rooms are customizable with three types of pillows, timber floors and granite bathrooms, while a stone-and-oak onsen (thermal baths) hits the spot after a day on the slopes. Rooms from $157.

Travel + Leisure: America's Best Ski Towns

The Sutton Place Hotel/Revelstoke Mountain Resort, Revelstoke, British Columbia, Canada

Under the gaze of Mount Mackenzie, Revelstoke Mountain Resort debuted in 2007. It counts five lifts and 59 runs (with more of both in the works) and is now the only resort in the world to offer lift, cat-, heli-, and backcountry skiing from the same village. Cool kids stay at the luxurious Sutton Place Hotel for the condo-style rooms with gas fireplaces, the outdoor, year-round pool and hot tubs, and the fitness studio offering yoga sessions. Rooms from $149.

The Dom, Saas Fee, Switzerland

The oldest hotel in Saas-Fee was given a radical 2012 makeover that went from dowdy to sophisticated and romantic, with a price tag that's hard to find in Switzerland. In-room iPads control windows, TVs and temperature, while stone and weathered wood beams give the rooms a cozy alpine feel. Best of all: Big fluffy-down-topped beds offer unparalleled views of the surrounding mountains and glaciers. Rooms from $350.

Travel + Leisure: World's Scariest Ski Slopes

Altapura, Val Thorens, France

Altapura emanates aprs-ski opulence with a warm indoor/outdoor pool and Scandinavian-style interiors of light-colored wood draped in white faux fur and accented by giant snowflake cutouts. It's also the highest five-star hotel in Europe at 7,545 feet, replete with tepidarium and views of Les Trois Valles's six glaciers, toothsome peaks and 372 miles of ski-in, ski-out trails. Rooms from $300.

Basecamp Hotel, South Lake Tahoe, California

Arc'teryx meets Anthropologie at Lake Tahoe's newest place to stay. Just minutes from both the water and the Heavenly Mountain ski resort, Basecamp Hotel was designed with high-style adventurers in mind. Its 50 chic, sleepaway-camp-inspired rooms (some with bunk beds) substitute lanterns for lamps and survival guides for Gideon Bibles. Nightly group meals encourage hostel-like minglingas do the outdoor fire pits, where you'll find guests sharing s'mores and trading stories about the moguls on Heavenly's famous Gunbarrel run. Rooms from $104.

Hotel Jerome, Aspen, Colorado

Auberge Resorts swooped in to give the historic Hotel Jerome a 2012 restoration and generate some buzz. While the grand fireplace and historic ballroom remain, a new lobby living room, a spa and a yoga studio have been added. The upgraded restaurant, bar and rooms take inspiration from old-time Hollywood glamour; John Wayne, Lana Turner and Hunter S. Thompson are all former hotel guests. Rooms from $640.

See the rest of the best new mountain resorts.

Matt Villano contributed to this story.

Planning a getaway? Don't miss Travel + Leisure's guide to the World's Best Hotels

Copyright 2012 American Express Publishing Corporation. All rights reserved.


Via: Best new mountain resorts

Source: http://travelbreakingnews.blogspot.com/2013/01/best-new-mountain-resorts.html

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Israel to give Palestine $100 million in withheld tax revenues

Israel to give Palestine $100 million in withheld tax revenues

January 30, 2013 - 11:17 AMT

PanARMENIAN.Net - Israel will give Palestinian President Mahmoud Abbas's administration around $100 million in tax revenues that had been withheld in retaliation for his statehood bid in the United Nations, Israeli officials said on Wednesday, January 30, according to Reuters.

They described the handover as a one-time deal, signaling rightist Israeli Prime Minister Benjamin Netanyahu had not formally scrapped sanctions that have hurt the Palestinian Authority in the occupied West Bank and worried world powers.

But the decision follows surprise setbacks for Netanyahu in a national election this month that, while giving him enough of a lead to head the next Israeli government, also set the stage for more moderate statecraft by boosting centrist challengers whom he must now consider as coalition partners.

Under interim peace deals, Israel collects some $100 million a month in duties on behalf of the Palestinian Authority, money Abbas badly needs to pay public sector salaries. It began withholding the funds after Abbas, sidestepping stalled diplomacy, secured a Palestinian status upgrade at the United Nations in November.

Israel said the December levies would be used instead to start paying off $200 million the Palestinians owe the Israel Electric Corporation, and predicted at the time that the lien on PA funds would be in force until March at least.

Israel has previously frozen payments to the PA during times of heightened security and diplomatic tensions, provoking strong international criticism, such as when the U.N. cultural body UNESCO granted the Palestinians full membership in 2011.

Source: http://www.panarmenian.net/eng/news/143500/

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Facebook 4Q results surpass expectations

NEW YORK (AP) ? Facebook delivered fourth-quarter results above Wall Street's expectations on Wednesday and sought to show that it has finally transformed into a "mobile company."

But its stock dropped sharply in after-hours trading as investors placed more significance on the company's growing expenses rather than on its increasing user base and higher advertising revenue.

"Everything was slightly better than expected," said Wedbush Securities analyst Michael Pachter. "I don't see anything here that would make me want to sell the stock."

Nonetheless, Facebook's stock fell $1.34 cents, or 4.3 percent, to $29.90 in after-hours trading following the earnings report.

Facebook grew its revenue and increased the proportion of revenue that comes from mobile advertising ? a closely watched figure. But expenses also grew sharply. Also, the company said 2013 will be a year of "significant investments" and hiring as it focuses on long-term growth rather than short-term profits.

Facebook Inc., the world's largest social media company, earned $64 million, or 3 cents per share, in the October-December period. That's down from $360 million, or 14 cents per share, a year earlier when it was still a privately held company.

Revenue rose 40 percent to $1.59 billion from $1.13 billion, surpassing analysts' expectations of $1.51 billion.

Advertising revenue grew 41 percent to $1.33 billion, increasing at a faster clip than in the third quarter, when it climbed 36 percent to $1.09 billion.

Excluding special items, mainly related to stock compensation expenses, Menlo Park, Calif.-based Facebook earned 17 cents per share in the latest quarter.

Analysts polled by FactSet expected lower adjusted earnings of 15 cents per share.

"There were no major red flags," said Raymond James analyst Aaron Kessler. "I think expectations may have even been just a little bit higher" than analyst estimates indicated.

Facebook's biggest challenge lies in mobile devices. Most Facebook users access it using a mobile phone or tablet computer, yet the 9-year-old company only started showing mobile ads about 9 months ago.

"I think more people are starting to understand mobile is a great opportunity for us," CEO Mark Zuckerberg told analysts in a conference call. "It allows us to reach more people, we have more engagement from the people we reach and I think we will be able to make more money for each minute people spend with us on ... mobile devices."

Facebook has been trying to squeeze in more mobile adverting without alienating users who are more interested in conversing with their friends than being subjected to a marketing blitz. The company appears to be striking the right balance so far, based on the number of people still regularly using the mobile apps, Kessler said.

Facebook said it generated 23 percent, or $306 million, of advertising revenue from mobile, up from 14 percent or $153 million in the third quarter, the first time it disclosed such information.

While Facebook's accelerated revenue growth is a positive sign, there's still a feeling that the company could be doing even more to mine revenue from its mobile audience, Kessler said. He expected Facebook's mobile ad revenue to rise to 25 percent of the company's ad sales or about $350 million in the fourth quarter.

Facebook's monthly user base grew 25 percent from a year earlier to 1.06 billion accounts. About 680 million of them access Facebook using a mobile device each month. The company also said that the number of mobile users who access the site every day surpassed daily users on the Web for the first time in the fourth quarter.

As of the stock market's close on Wednesday, Facebook's stock was up 60 percent since the company's third-quarter earnings report came out in October. But it still hasn't hit its initial public offering price of $38.

The May 18 IPO was by far the biggest one for an Internet company since Google's in 2004, but the excitement quickly deflated.

Pachter suspects that investors may be worried Facebook's expenses are starting to outstrip its revenue growth. That was the case in the fourth quarter when the company's costs, excluding employee stock compensation, soared 67 percent from the previous year to $849 million, mainly due to hiring and infrastructure costs such as data centers and servers. And Facebook promises to keep on spending.

David Ebersman, Facebook's chief financial officer, said Facebook expects total expenses, excluding stock compensation costs, to grow by about 50 percent in 2013. In 2012, these costs amounted to $2.83 billion, an increase of 63 percent from 2011.

The company ended the year with 4,600 employees, a 44 percent increase from the end of 2011.

__

AP Technology Writer Michael Liedtke contributed to this story from San Francisco.

Source: http://news.yahoo.com/facebook-4q-results-surpass-expectations-213552731--finance.html

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Wednesday, January 30, 2013

Sensible Assistance For The Internet Hosting Requi | Liberty

Most people who create their initial web site usually do not realize that the information to the web site should have a hosting citrix property where by it really is saved. You will have to recognize website hosting to do this. A number of people starting out should know what styles they can have and what possibilities they have. On this page, new webmasters may find some tips relating to hosting.

When you are unable to identify a provider that entirely fits your needs, you may decide to decide on a back up web hosting internet site. This way you can can switch with tiny matter, as an alternative to waiting for an accident to sever your service.

Your online number ought to give you reside data in your site visitors. The best way to double-look at the visitors amounts given by your web hosting services are to set up visitors counter-top on the website landing page. Use these figures that will help you alter areas of your site to attract much more consumers.

Tend not to imagine that your web number will support your website for yourself. It really is your accountability to make sure there is nothing shed, so you should file backup your data on a regular basis. If your internet site is Search engine marketing rigorous, it is actually specially important to never take a risk on dropping everything function.

Find a web hosting services with plenty of room to permit your web site to grow. One particular page made up of Web coding may not use up too much place, but pictures and video tutorials swiftly gobble up room. Locate a program that offers you 100MB of room to develop your site in the following season roughly.

Make sure companies that you?re considering will fulfill all of your current needs. Make a list of capabilities that you?ll want, like junk e-mail filtering security.

An online hold normally has a online discussion board you must read it. When you see a great deal of online marketers publishing regularly, this means the hold is a reputable organization with satisfied consumers. If their discussion board is generally bare, or you will find no replies from staff to consumers, this is not the hold you would like to use.

Be aware of your web host?s assure coverage and whether or not they offer you money back if you?re unhappy. A respected organization gives you a reimbursement should you aren?t satisfied with your service in the initial 30 days. Some web hosting service services might exaggerate their quality with their advertisements.

As stated earlier in this article, you will probably find that a low cost web hosting service might not be your most cost effective option. Any person having to sustain a web-based reputation have to be able to depend on their website hosting support twenty-four hours a day, one week every week. Place the assistance of this write-up to get results for your online needs and come aside with the very best hosting possibilities!

Source: http://dwiminneapolis.com/business/sensible-assistance-for-the-internet-hosting-requi/

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Reading Can Boost A Child?s IQ By More Than Six Points

GalleyCat:

After looking at eight different studies of childhood development, researchers recently concluded that ?reading to a child in an interactive style raises his or her IQ by over 6 points.?

Read the whole story: GalleyCat

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Source: http://www.huffingtonpost.com/2013/01/30/reading-can-boost-a-child_n_2580550.html

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Judge OKs record $4B BP oil spill criminal settlement | Wisconsin ...

By MICHAEL KUNZELMAN
Associated Press

The Deepwater Horizon oil rig burns in the Gulf of Mexico on April 21, 2010. U.S. District Judge Sarah Vance on Tuesday approved an agreement for BP to plead guilty to manslaughter and other charges and pay $4 billion in criminal penalties for the company's role in the 2010 oil disaster in the Gulf of Mexico. (AP File Photo/Gerald Herbert)

NEW ORLEANS (AP) ? A federal judge on Tuesday approved an agreement for BP PLC to plead guilty to manslaughter and other charges and pay a record $4 billion in criminal penalties for the company?s role in the 2010 oil disaster in the Gulf of Mexico.

Before she ruled, U.S. District Judge Sarah Vance heard testimony from relatives of 11 workers who died when BP?s blown-out Macondo well triggered an explosion on the Deepwater Horizon drilling rig and started the spill.

BP agreed in November to plead guilty to charges involving the workers? deaths and for lying to Congress about the size of the spill from its broken well, which spewed more than 200 million gallons of oil. Much of it ended up in the Gulf and soiled the shorelines of several states. The company could have withdrawn from the agreement if Vance had rejected it.

Neither the Justice Department nor BP presented arguments to the judge before her decision in New Orleans.

Vance said the plea deal was ?just punishment? considering the risks of litigation for BP and the alternatives to the settlement. She told victims? relatives who were in court that she read their ?truly gut-wrenching? written statements and factored their words into her decision.

?I?ve heard and I truly understand your feelings and the losses you suffered,? she said.

She said she also believes BP executives should have personally apologized to family members.

?I think BP should have done that out of basic humanity,? she said.

The deal doesn?t resolve the federal government?s civil claims against BP. The company could pay billions more in penalties for environmental damage.

BP separately agreed to a settlement with lawyers for Gulf Coast residents and businesses who claim the spill cost them money. BP estimates the deal with private attorneys will cost the company roughly $7.8 billion.

For the criminal settlement, BP agreed to pay nearly $1.3 billion in fines. The largest previous corporate criminal penalty assessed by the Justice Department was a $1.2 billion fine against drug maker Pfizer in 2009.

The criminal settlement also includes payments of nearly $2.4 billion to the National Fish and Wildlife Foundation and $350 million to the National Academy of Sciences.

In a court filing before the hearing, attorneys for BP and the Justice Department argued that the plea agreement imposes ?severe corporate punishment? and will deter BP and other deep-water drilling companies from allowing another disaster to occur.

The Justice Department has reached a separate settlement with rig owner Transocean Ltd. that resolves the government?s civil and criminal claims over the Swiss-based company?s role in the disaster.

Transocean agreed to plead guilty to a misdemeanor charge of violating the Clean Water Act and pay $1.4 billion in civil and criminal penalties. U.S. District Judge Jane Triche Milazzo has scheduled a Feb. 14 hearing to decide whether to accept that criminal settlement. A different judge will decide whether to accept Transocean?s civil settlement.

Many relatives of rig workers who died in the blast submitted written statements that were critical of BP?s deal. Twenty-eight-year-old Gordon Jones? family members said BP?s sentence should include a personal, face-to-face apology to his widow and children by BP executives. A brother of Jones also had urged Vance to consider stiffer penalties that prohibit or limit the company?s ability to operate in U.S. waters.

Vance, however, said she couldn?t get involved in plea negotiations and only could impose a sentence that adheres to the agreed-upon terms if she accepted it.

Also killed were Jason Anderson, 35, of Midfield, Texas; Aaron Dale ?Bubba? Burkeen, 37, of Philadelphia, Miss.; Donald Clark, 49, of Newellton, La.; Stephen Ray Curtis, 40, of Georgetown, La.; Roy Wyatt Kemp, 27, Jonesville, La.; Karl Kleppinger Jr., 38, of Natchez, Miss.; Keith Blair Manuel, 56, of Gonzales, La.; Dewey A. Revette, 48, of State Line, Miss.; Shane M. Roshto, 22, of Liberty, Miss.; and Adam Weise, 24, Yorktown, Texas.

Four current or former BP employees have been indicted on separate criminal charges. BP rig supervisors Robert Kaluza and Donald Vidrine are charged with manslaughter, accused of repeatedly disregarding abnormal high-pressure readings that should have been glaring indications of trouble just before the blowout.

David Rainey, BP?s former vice president of exploration for the Gulf of Mexico, was charged with withholding information from Congress about the amount of oil that was gushing from the well.

Former BP engineer Kurt Mix was charged with deleting text messages about the company?s spill response.

A series of government investigations have blamed the April 20, 2010, blowout on time-saving, cost-cutting decisions by BP and its partners on the drilling project.

Source: http://wislawjournal.com/2013/01/29/judge-oks-4b-bp-oil-spill-criminal-settlement/

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Atlanta: We're Casting for Our Next Film on Blended Families | Black ...

Tyler New Media is casting for a full length multi-cultural film on blended families (step-parenting etc?) set to release later this year. We?re looking for people that have been impacted in both good and negative ways from being a part of a blended family situation. Filming will take place on Tuesday February 5, 2013 through Friday February 8, 2013 in the Atlanta area. You would need to be available for approx. up to 3 hours on one of those days in the Atlanta area. If interested fill out the form and we?ll contact you shortly.


About the author

Lamar Tyler is co-creator BlackandMarriedWithKids.com. He also is the co-producer of the films Happily Ever After: A Positive Image of Black Marriage, You Saved Me, Men Ain?t Boys and Still Standing.


Source: http://blackandmarriedwithkids.com/2013/01/atlanta-were-casting-for-our-next-film-on-blended-families/

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Cool, new views of Andromeda galaxy

Jan. 28, 2013 ? Two new eye-catching views from the Herschel space observatory are fit for a princess. They show the elegant spiral galaxy Andromeda, named after the mythical Greek princess known for her beauty.

The Andromeda galaxy, also known as Messier 31, lies 2 million light-years away, and is the closest large galaxy to our own Milky Way. It is estimated to have up to one trillion stars, whereas the Milky Way contains hundreds of billions. Recent evidence suggests Andromeda's overall mass may in fact be less than the mass of the Milky Way, when dark matter is included.

Herschel, a European Space Agency mission with important NASA contributions, sees the longer-wavelength infrared light from the galaxy, revealing its rings of cool dust. Some of this dust is the very coldest in the galaxy -- only a few tens of degrees above absolute zero.

In both views, warmer dust is highlighted in the central regions by different colors. New stars are being born in this central, crowded hub, and throughout the galaxy's rings in dusty knots. Spokes of dust can also be seen between the rings.

One view, seen at http://www.jpl.nasa.gov/spaceimages/details.php?id=PIA16682 , is a mosaic of data from Herschel's Photodetecting Array Camera and Spectrometer (PACS) and spectral and photometric imaging receiver (SPIRE).

The second view, seen at http://www.jpl.nasa.gov/spaceimages/details.php?id=PIA16681 , shows data from only the SPIRE instrument, which captures the longest of wavelengths detectable by Herschel.

Herschel is a European Space Agency cornerstone mission, with science instruments provided by consortia of European institutes and with important participation by NASA. NASA's Herschel Project Office is based at NASA's Jet Propulsion Laboratory, Pasadena, Calif. JPL contributed mission-enabling technology for two of Herschel's three science instruments. The NASA Herschel Science Center, part of the Infrared Processing and Analysis Center at the California Institute of Technology in Pasadena, supports the United States astronomical community. Caltech manages JPL for NASA.

More information is online at http://www.herschel.caltech.edu , http://www.nasa.gov/herschel and http://www.esa.int/SPECIALS/Herschel .

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/X5WUouTdFgU/130128224157.htm

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Tuesday, January 29, 2013

Lenovo ThinkStation C30


The Lenovo ThinkStation C30 is a high-end, dual-processor workstation for those users who need to work on multi-stage, multi-quarter, multi-million dollar projects for you business. As is, the C30 is a tabula rasa to which you can add components and programs. With drive upgrades, it can work as a video workstation. With a CAD program, it can help your engineers design new cars. With a connection to the world's financial infodump, it can be a financial wizard's crystal ball. If you think you need his kind of power, the ThinkStation C30 will deliver it.

Design and Features
The ThinkStation C30 comes in a standard black metal desktop chassis, measuring about 17 by 5 by 17.5 inches (HWD). This is approximately the same size as our Editors' Choice for single-processor workstations, the HP Z220 CMT. What's amazing is that Lenovo has stuffed two processors into the C30, along with all the other internal connectors and components you'd expect from a full blown ISV-certified workstation. The front panel is perforated, like its much larger brother, the Lenovo ThinkStation D30. Instead of a handle that extends from the top of the system like on the Lenovo D30, the C30's grab handle is indented into the top panel. The front panel has a pair of USB 2.0 ports, audio ports, and the tray-loading DVD burner. The system's serial port, eight more USB 2.0 ports, and two USB 3.0 ports populate the back panel. You have room to add an eSATA with a pass-through card slot cover. If you do, you'll have to use PCIe to add Thunderbolt to the C30.

Inside, it's a little more cramped than a full tower, but Lenovo still manages to have two PCI slots (for those older expansion cards), two free PCIe x16 card slots (for graphics cards), a free PCIe x4 slot, and space for two more hard drives. You'll have to pop off the front panel to access the hard drive sleds, which are tool less. An 800-Watt power supply powers the system. On the whole, the C30 has better internal expansion options than the former Editors' Choice Dell Precision T1600 workstation. The larger Apple Mac Pro has more room for drives, but until the expected update later this year, the Mac Pro's older-generation Xeon processors, fewer expansion slots, and lack of Nvidia Quadro or AMD FirePro configurations lags the C30.

The C30 comes with two Intel Xeon E5-2620 processors, 16GB of ECC DDR3 system memory, Nvidia Quadro 4000 graphics, and a 500GB hard drive. These components make a good base for a DCC (digital content creation), CAD, or number crunching workstation, especially considering that the system can accept a plethora of upgrades. The system's rack mount option also means that you can put a stack of these powerful dreadnoughts in a sound proofed and climate controlled closet.

The system we tested came with Windows 7 Professional, but you can buy one without an OS in case your IT folk want to use Windows XP, Linux, or even Windows 8. You can set up the system with up to three drives for RAID 0, 1, or 5. The C30 comes with a standard three-year warranty, which can be extended up to five years, with or without on-site service.

Performance
Lenovo ThinkStation C30 The system's performance and reliability are the primary reasons you get a workstation over a standard business PC, and the ThinkStation C30 has a lot of it. The system's two six-core Xeon processors make short work of most tasks, surprising considering the processors are "only" clocked at 2GHz standard (2.5GHz with Turbo-Boost). The C30's Photoshop CS6 (4 hours 17 minutes) and Handbrake video encoder test (1:45) scores are good, though the business-class Apple iMac 27-inch (Late 2012) is faster due in part to its use of Apple's Fusion drive.

The C30 has a high CineBench score, showing that it has better threaded performance (like 3D rendering) than the iMac and other single-processor systems. The Nvidia Quadro in the C30 is tuned for reliable, repeatable results rather than all-out 3D performance, but it's nice to know that the C30 still ended up with excellent 3D benchmark scores. You can hook up two 30-inch monitors simultaneously to the Quadro 4000, which will help your engineer's productivity immensely.

The Lenovo ThinkStation C30 is a very good dual-processor workstation. It is a powerhouse for the space constrained financial, DCC, or engineering user in your organization. The system therefore comes highly recommended, but its roomier, more powerful, and more expensive big brother the Lenovo ThinkStation D30 holds on to the Editors' Choice for dual-processor workstations for the time being for having a lot more power and being more flexible for future upgrades.

BENCHMARK TEST RESULTS

COMPARISON TABLE
Compare the Lenovo ThinkStation C30 with several other desktops side by side.

More desktop reviews:
??? Lenovo ThinkStation C30
??? Lenovo IdeaCentre B540
??? Toshiba LX835-D3380
??? Dell XPS One 27 Touch
??? Intel Next Unit of Computing Kit DC3217BY
?? more

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Money fears vs. real benefits in Medicaid choice (The Arizona Republic)

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Patients' own skin cells are transformed into heart cells to create 'disease in a dish'

Jan. 27, 2013 ? Most patients with an inherited heart condition known as arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) don't know they have a problem until they're in their early 20s. The lack of symptoms at younger ages makes it very difficult for researchers to study how ARVD/C evolves or to develop treatments. A new stem cell-based technology created by 2012 Nobel Prize winner Shinya Yamanaka, M.D., Ph.D., helps solve this problem. With this technology, researchers can generate heart muscle cells from a patient's own skin cells. However, these newly made heart cells are mostly immature. That raises questions about whether or not they can be used to mimic a disease that occurs in adulthood.

In a paper published January 27 in Nature, researchers at Sanford-Burnham Medical Research Institute and Johns Hopkins University unveil the first maturation-based "disease in a dish" model for ARVD/C. The model was created using Yamanaka's technology and a new method to mimic maturity by making the cells' metabolism more like that in adult hearts. For that reason, this model is likely more relevant to human ARVD/C than other models and therefore better suited for studying the disease and testing new treatments.

"It's tough to demonstrate that a disease-in-a-dish model is clinically relevant for an adult-onset disease. But we made a key finding here -- we can recapitulate the defects in this disease only when we induce adult-like metabolism. This is an important breakthrough considering that ARVD/C symptoms usually don't arise until young adulthood. Yet the stem cells we're working with are embryonic in nature," said Huei-Sheng Vincent Chen, M.D., Ph.D., associate professor at Sanford-Burnham and senior author of the study.

To establish this model, Chen teamed up with expert ARVD/C cardiologists Daniel Judge, M.D., Joseph Marine, M.D., and Hugh Calkins, M.D., at Johns Hopkins University. Johns Hopkins is home to one of the largest ARVD/C patient registries in the world.

"There is currently no treatment to prevent progression of ARVD/C, a rare disorder that preferentially affects athletes. With this new model, we hope we are now on a path to develop better therapies for this life-threatening disease," said Judge, associate professor and medical director of the Center for Inherited Heart Disease at the Johns Hopkins University School of Medicine.

Disease in a dish

To recreate a person's own unique ARVD/C in the lab, the team first obtained skin samples from ARVD/C patients with certain mutations believed to be involved in the disease. Next they performed Yamanaka's technique: adding a few molecules that dial back the developmental clock on these adult skin cells, producing embryonic-like induced pluripotent stem cells (iPSCs). The researchers then coaxed the iPSCs into producing an unlimited supply of patient-specific heart muscle cells. These heart cells were largely embryonic in nature, but carried along the original patient's genetic mutations.

However, for nearly a year, no matter what they tried, the team couldn't get their ARVD/C heart muscle cells to show any signs of the disease. Without actual signs of adult-onset ARVD/C, these young, patient-specific heart muscle cells were no use for studying the disease or testing new therapeutic drugs.

Speeding up time

Eventually, the team experienced the big "aha!" moment they'd been looking for. They discovered that metabolic maturity is the key to inducing signs of ARVD/C, an adult disease, in their embryonic-like cells. Human fetal heart muscle cells use glucose (sugar) as their primary source of energy. In contrast, adult heart muscle cells prefer using fat for energy production. So Chen's team applied several cocktails to trigger this shift to adult metabolism in their model.

After more trial and error, they discovered that metabolic malfunction is at the core of ARVD/C disease. Moreover, Chen's team tracked down the final piece of puzzle to make patient-specific heart muscle cells behave like sick ARVD/C hearts: the abnormal over-activation of a protein called PPAR?. Scientists previously attributed ARVD/C to a problem in weakened connections between heart muscle cells, which occur only in half of the ARVD/C patients. With the newly established model, they not only replicated this adult-onset disease in a dish, but also presented new potential drug targets for treating ARVD/C.

What's next?

Chen's team was recently awarded a new grant from the California Institute for Regenerative Medicine to create additional iPSC-based ARVD/C models. With more ARVD/C models, they will determine whether or not all (or at least most) patients develop the disease via the same metabolic defects discovered in this current study.

Together with the Johns Hopkins team, Chen also hopes to conduct preclinical studies to find a new therapy for this deadly heart condition.

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Story Source:

The above story is reprinted from materials provided by Sanford-Burnham Medical Research Institute, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Changsung Kim, Johnson Wong, Jianyan Wen, Shirong Wang, Cheng Wang, Sean Spiering, Natalia G. Kan, Sonia Forcales, Pier Lorenzo Puri, Teresa C. Leone, Joseph E. Marine, Hugh Calkins, Daniel P. Kelly, Daniel P. Judge, Huei-Sheng Vincent Chen. Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs. Nature, 2013; DOI: 10.1038/nature11799

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/SopuqUp_z60/130127134201.htm

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Study: Distant rural areas may feel cities' heat

WASHINGTON (AP) ? Heat rising up from cities such as New York, Paris and Tokyo might be remotely warming up winters far away in some rural parts of Alaska, Canada, and Siberia, a surprising study theorizes.

In an unusual twist, that same urban heat from buildings and cars may be slightly cooling the autumns in much of the Western United States, Eastern Europe and the Mediterranean, according to the study published Sunday in the scientific journal Nature Climate Change.

Meteorologists long have known that cities are warmer than rural areas, with the heat of buildings and cars, along with asphalt and roofs that absorb heat. That's called the urban heat island effect and it's long been thought that the heat stayed close to the cities.

But the study, based on a computer model and the Northern Hemisphere, now suggests the heat does something else, albeit indirectly. It travels about half a mile up into the air and then its energy changes the high-altitude currents in the atmosphere that dictate prevailing weather.

"Basically, it changes the flow." said Guang Zhang of the Scripps Institution of Oceanography in La Jolla, Calif. He wrote the paper with Aixue Hu at the National Center for Atmospheric Research in Boulder, Colo.

This doesn't change overall global temperature averages significantly, unlike man-made greenhouse gases that cause global warming. Instead it redistributes some of the heat, the scientists said.

The changes seem to vary with the seasons and by region because of the way air currents flow at different times of the year. During the winter, the jet stream is altered and weakened, keeping cold air closer to the Arctic Circle and from dipping down as sharply, Hu explained.

The computer model showed that parts of Siberia and northwestern Canada may get, on average, an extra 1.4 degrees to 1.8 degrees Fahrenheit (0.8 to 1 degree Celsius) during the winter, which "may not be a bad thing," Zhang said. The effect isn't quite as much in northern North Dakota and Minnesota, where temperatures might be about half a degree warmer (0.3 degrees Celsius), and even less along the East Coast.

In contrast, Europe and the Pacific Northwest are cooled slightly in the winter from this effect. The jet stream changes prevent weather systems from bringing warmer air from the Atlantic to Europe and from the Pacific to the U.S. Northwest, thus cooling those areas a bit, he said.

The biggest cooling occurs in the fall, but Hu said he's not quite sure why that happens.

Several outside scientists said they were surprised by the study results, calling the work "intriguing" and "clever." But they said it would have to be shown in more than one computer model and in repeated experiments before they could accept this theory.

"It's an interesting and rationally carried out study," said David Parker, climate monitoring chief of the United Kingdom meteorology office. "We must be cautious until other models are used to test their hypothesis."

___

Online:

Nature Climate Change: http://www.nature.com/nclimate

___

Seth Borenstein can be followed at http://twitter.com/borenbears

Source: http://news.yahoo.com/study-distant-rural-areas-may-feel-cities-heat-180509317.html

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Monday, January 28, 2013

Health care among early leaders in the S&P 500

NEW YORK (AP) ? Health care stocks have started off the year on a tear.

The industry group that includes health care providers, drugmakers and biotechnology companies has advanced 7.3 percent this year, making it the second-best in the Standard and Poor's 500 index, trailing only energy companies. Even drugmakers, traditionally considered a safe-haven play, are outperforming the market.

The rally has solid foundations, but not all companies will benefit equally from the influx of cash. Also, the wide range of stocks in the sector offer investors vastly differing risk and return dynamics.

U.S. health care spending is projected to climb at a faster pace than economic growth in coming years as the population ages and President Barack Obama's Affordable Care Act gives millions of Americans greater access to care.

The Centers for Medicare and Medicaid Services projects that total health care spending will rise 70 percent over last year's estimated level of $2.8 trillion to $4.8 trillion by 2021. That's almost 20 percent of U.S. gross domestic product.

"There's just a lot more money flowing into health care and we're seeing the markets react accordingly," says Derek Taner, a portfolio manager at Invesco.

President Obama's re-election in November gave the sector a boost by removing the uncertainty surrounding the implementation of the Affordable Care Act. Republican candidate Mitt Romney had said that he would overturn the act if elected.

The biggest beneficiaries of the act will likely be hospital companies, which have the potential to increase their earnings significantly, says Taner, who manages Invesco's Global Health Care fund.

So-called managed-care companies should also benefit from the increase in spending, though they also face higher taxes and restrictions on how they can price their coverage, so the law will be challenging to them too.

HCA Holdings Inc., a bellwether for the hospital industry, has gained 25 percent so far this year. Tenet Healthcare Corp., a Dallas-based operator of acute care hospitals, has advanced 20 percent.

Drugmakers, often regarded as defensive growth companies by analysts, are also emerging from the doldrums after lagging the broader index for much of the last decade.

Pfizer Inc., the world's biggest drugmaker by revenue, has returned 31 percent over the last 10 years, compared with 113 percent for the S&P 500.

The big pharmaceutical companies were shunned by investors as they faced challenges from rising research costs and the economic slump in Europe, which prompted governments to try to rein in health care spending.

Drug companies were also hurt by what the industry dubbed the "patent cliff," as an unprecedented number of patents expired on drugs worth billions of dollars in sales. The expiration of patents allows cheaper generic versions of drugs to replace blockbuster products. That hurts sales.

Pfizer lost exclusivity for its cholesterol-fighting drug Lipitor in the U.S. in November 2011. In its most recent earnings report, Pfizer said that U.S. revenues from the drug plunged 87 percent in the third quarter of 2012 to $192 million. The company will release its fourth-quarter earnings Tuesday.

The worst of the impact of patent expiration may now be over for the drugmakers, and the market has already factored it into stock prices, says Mark Bussard, a health care analyst at fund manager T. Rowe Price.

"The 'patent cliff' for most of the companies has now come and gone," says Bussard, who is a physician by training. "Some of the largest losses to generic competition are in the rear-view mirror now."

Approvals for first-of-a-kind drugs have also been climbing as drugmakers continue to pursue an emerging business model focused on treatments for rare and hard-to-treat diseases.

The Food and Drug Administration approved 39 new drugs last year, up from 30 the year before and the highest annual tally since 1997, when the agency also approved 39 drugs.

In addition to being relatively low-risk investments, due to the steady demand for drugs, Big Pharma also pays big dividends.

The largest drug companies in the S&P 500 have higher dividend yields than the broader index, which yields 2.1 percent. Pfizer currently has a 3.6 percent yield and Merck & Co. yields 4 percent.

Biotechnology companies are possibly the most exciting companies in the sector and are also advancing.

Investing in this sector can be challenging, though, as the vast majority of drugs being developed don't work out.

"It's probably unwise ... to try to pick the individual winner," says Sam Isaly, the manager of Eaton Vance's Worldwide Health Sciences Fund. "It depends on whether you're a lotto player or not."

While the Affordable Care Act ensures that money will flow into the industry in the near term, that spending can't keep rising exponentially. At some point, the focus will turn to the cost of the reforms, particularly if the initial spending estimates are exceeded, causing renewed uncertainty for the industry.

"That's a longer-term concern that is going to come into play at some point," says Invesco's Taner. "Right now we're in the honeymoon period. People aren't thinking about that."

And if history is a guide, the cost estimates will likely prove too low.

Upon passing the Medicare bill in 1965, the House Ways and Means Committee estimated total program expenditures would amount to $1.3 billion in 1967. That estimate proved to be "wildly optimistic," with the actual cost coming in at $4.6 billion, according to research by Citigroup health care analysts.

To counter the rising costs, governments and employers will increasingly try to shift more of the cost to individual consumers, transforming the industry from an "employer-driven insurance market" to an "employee-driven consumer market," says Eddie Yoon of Fidelity.

"The companies that are the most innovative in helping drive costs down are going to be the growth companies of tomorrow," says Yoon, who manages the investment firm's Select Health Care Portfolio.

___

AP Business Writers Matthew Perrone and Linda Johnson contributed.

Source: http://news.yahoo.com/health-care-among-early-leaders-p-500-231523801--finance.html

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The Human Brain Project: Winner of the of the largest European scientific funding competition

The Human Brain Project: Winner of the of the largest European scientific funding competition [ Back to EurekAlert! ] Public release date: 28-Jan-2013
[ | E-mail | Share Share ]

Contact: Anita Kar
anita.kar@mcgill.ca
514-398-3376
McGill University

The European Commission has officially announced the selection of the Human Brain Project (HBP) as one of its two FET Flagship projects. The new project will federate European efforts to address one of the greatest challenges of modern science: understanding the human brain.

The goal of the Human Brain Project is to pull together all our existing knowledge about the human brain and to reconstruct the brain, piece by piece, in supercomputer-based models and simulations. The models offer the prospect of a new understanding of the human brain and its diseases and of completely new computing and robotic technologies. On January 28, the European Commission supported this vision, announcing that it has selected the HBP as one of two projects to be funded through the new FET Flagship Program.

Federating more than 80 European and international research institutions, the Human Brain Project is planned to last ten years (2013-2023). The cost is estimated at 1.19 billion euros. The project will also associate some important North American and Japanese partners. It will be coordinated at the Ecole Polytechnique Fdrale de Lausanne (EPFL) in Switzerland, by neuroscientist Henry Markram with co-directors Karlheinz Meier of Heidelberg University, Germany, and Richard Frackowiak of Centre Hospitalier Universitaire Vaudois (CHUV) and the University of Lausanne (UNIL).

Canada's role in this international project is through Dr. Alan Evans of the Montreal Neurological Institute (MNI) at McGill University. His group has developed a high-performance computational platform for neuroscience (CBRAIN) and multi-site databasing technologies that will be used to assemble brain imaging data across the HBP. He is also collaborating with European scientists on the creation of ultra high-resolution 3D brain maps. This ambitious project will integrate data across all scales, from molecules to whole-brain organization. It will have profound implications for our understanding of brain development in children and normal brain function, as well as for combatting brain disorders such as Alzheimer's Disease, said Dr. Evans. "The MNI's pioneering work on brain imaging technology has led to significant advances in our understanding of the brain and neurological disorders," says Dr. Guy Rouleau, Director of the MNI. "I am proud that our expertise is a key contributor to this international program focused on improving quality of life worldwide."

"The Canadian Institutes of Health Research (CIHR) is delighted to acknowledge the outstanding contributions of Dr. Evans and his team. Their work on the CBRAIN infrastructure and this leading-edge HBP will allow the integration of Canadian neuroscientists into an eventual global brain project," said Dr. Anthony Phillips, Scientific Director for the CIHR Institute of Neurosciences, Mental Health and Addiction. "Congratulations to the Canadian and European researchers who will be working collaboratively towards the same goal which is to provide insights into neuroscience that will ultimately improve people's health."

"From mapping the sensory and motor cortices of the brain to pioneering work on the mechanisms of memory, McGill University has long been synonymous with world-class neuroscience research," says Dr. Rose Goldstein, Vice-Principal (Research and International Relations). "The research of Dr. Evans and his team marks an exciting new chapter in our collective pursuit to unlock the potential of the human brain and the entire nervous system a critical step that would not be possible without the generous support of the European Commission and the FET Flagship Program."

The selection of the Human Brain Project as a FET Flagship is the result of more than three years of preparation and a rigorous and severe evaluation by a large panel of independent, high profile scientists, chosen by the European Commission. In the coming months, the partners will negotiate a detailed agreement with the Community for the initial first two and a half year ramp-up phase (2013-mid 2016). The project will begin work in the closing months of 2013.

###

The Neuro

The Montreal Neurological Institute and Hospital The Neuro, is a unique academic medical centre dedicated to neuroscience. Founded in 1934 by the renowned Dr. Wilder Penfield, The Neuro is recognized internationally for integrating research, compassionate patient care and advanced training, all key to advances in science and medicine. The Neuro is a research and teaching institute of McGill University and forms the basis for the Neuroscience Mission of the McGill University Health Centre.

Neuro researchers are world leaders in cellular and molecular neuroscience, brain imaging, cognitive neuroscience and the study and treatment of epilepsy, multiple sclerosis and neuromuscular disorders. For more information, visit theneuro.com.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


The Human Brain Project: Winner of the of the largest European scientific funding competition [ Back to EurekAlert! ] Public release date: 28-Jan-2013
[ | E-mail | Share Share ]

Contact: Anita Kar
anita.kar@mcgill.ca
514-398-3376
McGill University

The European Commission has officially announced the selection of the Human Brain Project (HBP) as one of its two FET Flagship projects. The new project will federate European efforts to address one of the greatest challenges of modern science: understanding the human brain.

The goal of the Human Brain Project is to pull together all our existing knowledge about the human brain and to reconstruct the brain, piece by piece, in supercomputer-based models and simulations. The models offer the prospect of a new understanding of the human brain and its diseases and of completely new computing and robotic technologies. On January 28, the European Commission supported this vision, announcing that it has selected the HBP as one of two projects to be funded through the new FET Flagship Program.

Federating more than 80 European and international research institutions, the Human Brain Project is planned to last ten years (2013-2023). The cost is estimated at 1.19 billion euros. The project will also associate some important North American and Japanese partners. It will be coordinated at the Ecole Polytechnique Fdrale de Lausanne (EPFL) in Switzerland, by neuroscientist Henry Markram with co-directors Karlheinz Meier of Heidelberg University, Germany, and Richard Frackowiak of Centre Hospitalier Universitaire Vaudois (CHUV) and the University of Lausanne (UNIL).

Canada's role in this international project is through Dr. Alan Evans of the Montreal Neurological Institute (MNI) at McGill University. His group has developed a high-performance computational platform for neuroscience (CBRAIN) and multi-site databasing technologies that will be used to assemble brain imaging data across the HBP. He is also collaborating with European scientists on the creation of ultra high-resolution 3D brain maps. This ambitious project will integrate data across all scales, from molecules to whole-brain organization. It will have profound implications for our understanding of brain development in children and normal brain function, as well as for combatting brain disorders such as Alzheimer's Disease, said Dr. Evans. "The MNI's pioneering work on brain imaging technology has led to significant advances in our understanding of the brain and neurological disorders," says Dr. Guy Rouleau, Director of the MNI. "I am proud that our expertise is a key contributor to this international program focused on improving quality of life worldwide."

"The Canadian Institutes of Health Research (CIHR) is delighted to acknowledge the outstanding contributions of Dr. Evans and his team. Their work on the CBRAIN infrastructure and this leading-edge HBP will allow the integration of Canadian neuroscientists into an eventual global brain project," said Dr. Anthony Phillips, Scientific Director for the CIHR Institute of Neurosciences, Mental Health and Addiction. "Congratulations to the Canadian and European researchers who will be working collaboratively towards the same goal which is to provide insights into neuroscience that will ultimately improve people's health."

"From mapping the sensory and motor cortices of the brain to pioneering work on the mechanisms of memory, McGill University has long been synonymous with world-class neuroscience research," says Dr. Rose Goldstein, Vice-Principal (Research and International Relations). "The research of Dr. Evans and his team marks an exciting new chapter in our collective pursuit to unlock the potential of the human brain and the entire nervous system a critical step that would not be possible without the generous support of the European Commission and the FET Flagship Program."

The selection of the Human Brain Project as a FET Flagship is the result of more than three years of preparation and a rigorous and severe evaluation by a large panel of independent, high profile scientists, chosen by the European Commission. In the coming months, the partners will negotiate a detailed agreement with the Community for the initial first two and a half year ramp-up phase (2013-mid 2016). The project will begin work in the closing months of 2013.

###

The Neuro

The Montreal Neurological Institute and Hospital The Neuro, is a unique academic medical centre dedicated to neuroscience. Founded in 1934 by the renowned Dr. Wilder Penfield, The Neuro is recognized internationally for integrating research, compassionate patient care and advanced training, all key to advances in science and medicine. The Neuro is a research and teaching institute of McGill University and forms the basis for the Neuroscience Mission of the McGill University Health Centre.

Neuro researchers are world leaders in cellular and molecular neuroscience, brain imaging, cognitive neuroscience and the study and treatment of epilepsy, multiple sclerosis and neuromuscular disorders. For more information, visit theneuro.com.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-01/mu-thb012813.php

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Saturday, January 26, 2013

Socially isolated rats are more vulnerable to addiction, report researchers

Thursday, January 24, 2013

Rats that are socially isolated during a critical period of adolescence are more vulnerable to addiction to amphetamine and alcohol, found researchers at The University of Texas at Austin. Amphetamine addiction is also harder to extinguish in the socially isolated rats.

These effects, which are described this week in the journal Neuron, persist even after the rats are reintroduced into the community of other rats.

"Basically the animals become more manipulatable," said Hitoshi Morikawa, associate professor of neurobiology in the College of Natural Sciences. "They're more sensitive to reward, and once conditioned the conditioning takes longer to extinguish. We've been able to observe this at both the behavioral and neuronal level."

Morikawa said the negative effects of social isolation during adolescence have been well documented when it comes to traits such as anxiety, aggression, cognitive rigidity and spatial learning. What wasn't clear until now is how social isolation affects the specific kind of behavior and brain activity that has to do with addiction.

"Isolated animals have a more aggressive profile," said Leslie Whitaker, a former doctoral student in Morikawa's lab and now a researcher at the National Institute on Drug Abuse. "They are more anxious. Put them in an open field and they freeze more. We also know that those areas of the brain that are more involved in conscious memory are impaired. But the kind of memory involved in addiction isn't conscious memory. It's an unconscious preference for the place in which you got the reward. You keep coming back to it without even knowing why. That kind of memory is enhanced by the isolation."

The rats in the study were isolated from their peers for about a month from 21 days of age. That period is comparable with early-to-middle adolescence in humans. They were then tested to see how they responded to different levels of exposure to amphetamine and alcohol.

The results were striking, said Micka?l Degoulet, a postdoctoral researcher in Morikawa's lab. The isolated rats were much quicker to form a preference for the small, distinctive box in which they received amphetamine or alcohol than were the never-isolated control group. Nearly all the isolated rats showed a preference after just one exposure to either drug. The control rats only became conditioned after repeated exposures.

Morikawa said that this kind of preference for the environmental context in which the reward was received provides researchers with a more useful way of understanding addiction than seeing it as a desire for more of the addictive substance.

"When you drink or take addictive drugs, that triggers the release of dopamine," he said. "People commonly think of dopamine as a happy transmitter or a pleasure transmitter, which may or may not be true, but it is becoming increasingly clear that it is also a learning transmitter. It strengthens those synapses that are active when dopamine is released. It tells our brain that what we're doing at that moment is rewarding and thus worth repeating."

In an important sense, says Morikawa, you don't become addicted to the experience of pleasure or relief but to the constellation of environmental, behavioral and physiological cues that are reinforced when the substance triggers the release of dopamine in the brain.

Morikawa and Whitaker have also been able to document these changes at the neuronal level. Social isolation primes dopamine neurons in the rats' brain to quickly learn to generate spikes in response to inputs from other brain areas. So dopamine neurons will learn to respond to the context more quickly.

If the control, group-housed rats are given enough repeated exposure to amphetamine, they eventually achieve the same degree of addiction as the socially isolated rats. Even from this point of comparable addiction, however, there are differences. It takes longer for the socially isolated rats to kick the addiction to amphetamine when they're exposed to the same extinction protocols. (They spend time in the same environments, but amphetamine is no longer available.)

"So the social isolation leads to addiction more quickly, and it's harder to extinguish," said Whitaker.

Whitaker said that the implications of these findings for addiction in humans are obvious. There is a rich literature that documents the negative effects of social isolation in humans, as well as a great deal of evidence that addiction in rats and humans is functionally similar at the neurological level.

"It's not a one-to-one correlation, but there are socially impoverished human environments," she said. "There are children who are neglected, who have less social input. It's reasonable to make guesses about what the impact of that is going to be."

Morikawa points out that their findings may also have implications for how social isolation during adolescence affects conditionability when it comes to other kinds of rewards.

"We think that maybe what's happening is that the brain reacts to the impoverished environment, to a lack of opportunities to be reinforced by rewarding stimuli, by increasing its sensitivity to reward-based conditioning," said Morikawa. "The deprived brain may be overinterpreting any reward it encounters. And if that's the case, it's likely that you are more conditionable not only to drugs but to any sort of reward, including food reward. One interesting possibility is that it might also make adolescents more prone to food 'addiction,' and then to obesity."

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University of Texas at Austin: http://www.utexas.edu

Thanks to University of Texas at Austin for this article.

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Source: http://www.labspaces.net/126437/Socially_isolated_rats_are_more_vulnerable_to_addiction__report_researchers

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HTC-made au Infobar A02 launches in Japan, wraps unique Android UI in trippy body

HTC's au Infobar A02

KDDI's funky au Infobar is back! Once again designed by the famed Naoto Fukasawa, this A02 -- co-developed by HTC -- brings the series up to date with Qualcomm's 1.5GHz quad-core APQ8064 (but with just 1GB of RAM), 4.7-inch 720p display, 16GB of storage, microSD slot, 2,100mAh battery, LTE radio (800/1500) and Android 4.1. Better yet, this phone also supports both CDMA2000 800/2100 and WCDMA 850/1900/2100, making it a great global phone. Judging by one of the demo clips after the break, it seems that this Infobar's 8-megapixel main imager (with F2.0 lens) and 2.1-megapixel front-facing camera take advantage of HTC's ImageSense chip for speedy burst shots. Likewise, you'll find Beats Audio built into the system. As per typical Japanese mobile phone, the usual NFC (with Osaifu-Keitai mobile wallet), 1seg TV tuner and infrared are also packed inside the 9.7mm-thick, 147g-heavy waterproof (IPX5 and IPX7) and dustproof (IP5X) body.

We're already fans of the iconic nishikigoi (meaning "brocaded carp") color scheme as pictured above, but what really caught our attention this time are the fluid animations and uniqueness of the "iida UI" 2.0 (iida stands for "innovation," "imagination," "design" and "art") by interactive designer Yugo Nakamura. As you'll see in the video clips after the break, the home screen here shares some similarities with Windows Phone 8's counterpart -- in the way items snap to grid and resize, even though the former is enhanced by plenty of bouncy animation, more colors and funny sounds (designed by Japanese musician Cornelius). Expect this A02 -- which is also available in blue or gray -- to hit the Japanese market in mid-February.

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Via: Engadget Japanese

Source: KDDI (Japanese)

Source: http://www.engadget.com/2013/01/25/htc-au-infobar-a02/

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